Place the butter, lemon juice, zest, and minced garlic into a 9x13 baking dish.
Place the baking dish in the oven and preheat the oven to 400 degrees F. Allow the butter and lemon juice to combine as the butter melts. Once the butter is melted, remove it from the oven.
Lay the tilapia into the lemon, garlic butter, and season one side of the tilapia with salt, pepper, and red pepper. Flip the tilapia over and season the other side.
Add the sliced lemon on top of the fillets.
Bake it for 10-12 minutes until the fillets are white, tender, and still somewhat firm. When a fork goes through it, it will have a flaky texture.
Notes
Look for the freshest fish you can find, which means fillets that are firm, moist, and odorless.
Try to choose tilapia fillets that are about the same thickness so they’ll cook at the same rate.
Melt the butter directly in the baking dish while the oven is preheating instead of in a separate bowl in the microwave.
Check the tilapia for flakiness to see when it’s done. I use a fork to cut into the thickest part of the fish, and if it flakes easily, I know it’s ready.
Store leftovers in an airtight container in the refrigerator for up to 3 days.
To reheat leftovers, bake in a preheated oven at 350 degrees F on a baking sheet lined with parchment paper and covered with foil for 10-15 minutes until warmed through.
This nutrition information is based on the exact products I used in this recipe. Brands and sizes of products could alter exact nutrition and should always be calculated independently.