In a shallow bowl, whisk together flour, salt, paprika, garlic powder, onion powder, and pepper. In another shallow bowl, beat the egg with ½ tablespoon of water.
Press each pork chop into the flour mixture, coating both sides. Dip each side into the beaten egg, then dredge it through the flour mixture a second time. Allow the chops to sit at room temperature for 10-20 minutes, to help the flour adhere before cooking.
Preheat the air fryer to 400 degrees F.
Place the pork chops into the basket in a single layer. Spray the top with cooking oil spray and air fry for 8-10 minutes, carefully flipping halfway through cooking, until the internal temperature is 140-145 degrees F. If cooking thick pork chops, cook for 14-15 minutes.
Allow the chops to rest for 5-10 minutes, then serve with your favorite sides.